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Differential role of NF-κB, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice.

Cellular immunology - 1 Jan 2012

Guindi Chantal, Ménard Michaël, Cloutier Alexandre, Gaudreau Simon, Besin Gilles, Larivée Pierre, McDonald Patrick P, Dupuis Gilles, Amrani Abdelaziz

Abstract excerpt

Tolerogenic dendritic cells represent a promising immunotherapy in autoimmunity. However, the molecular mechanisms that drive tolerogenic DCs functions are not well understood. We used GM-CSF or GM-CSF+IL-4 to generate tolerogenic (GM/DCs) and immunogenic (IL-4/DCs) BMDCs from NOD mice, respectively. GM/DCs were resistant to maturation, produced large amounts of IL-10 but not IL-12p70. GM/DCs displayed a reduced...

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PMID: 22070873
DOI: 10.1016/j.cellimm.2011.10.005

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