Article
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998
Ren J, Esnouf R M, Hopkins A L, Jones E Y, Kirby I, Keeling J, Ross C K, Larder B A, Stuart D I, Stammers D K
Abstract excerpt
HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. Many of these drugs [e.g., 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI)] are analogues of the nucleoside substrates used by the HIV RT. One of the main problems in anti-HIV therapy is t...
Topics
- Binding Sites
- Crystallography, X-Ray
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- Mutation
- Protein Conformation
- Zidovudine