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Article

hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population.

Cancer science - 1 Jun 2011

Li Qian, Huang Lizhen, Rong Liucheng, Xue Yao, Lu Qin, Rui Yaoyao, Li Jie, Tong Na, Wang Meilin, Zhang Zhengdong, Fang Yongjun

Abstract excerpt

Oxidative DNA damage caused by reactive oxygen species can produce 8-oxoguanine (8-oxoG) in DNA, which is misread and leads to G:C→T:A transversions. This can be carcinogenic. Repair of 8-oxoG by the base excision repair pathway involves the activity of human 8-oxoG DNA glycosylase 1 (hOGG1). Accumulating evidence suggests that the hOGG1 Ser326Cys polymorphism affects the activity of hOGG1 and might serve as a...

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PMID: 21401806
DOI: 10.1111/j.1349-7006.2011.01928.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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