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Article

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.

Nature - 22 Jun 2017

Kuchay Shafi, Giorgi Carlotta, Simoneschi Daniele, Pagan Julia, Missiroli Sonia, Saraf Anita, Florens Laurence, Washburn Michael P, Collazo-Lorduy Ana, Castillo-Martin Mireia, Cordon-Cardo Carlos, Sebti Said M, Pinton Paolo, Pagano Michele

Abstract excerpt

In response to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the 'quasisynaptical' feeding of calcium to the mitochondria to promote oxidative phosphorylation. However, persistent Ca2+ release results in mitochondrial Ca2+ overload and consequent apoptosis. Among the three mammalian IP3Rs, IP3R3 appears to be the...

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Source

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Identifiers

PMID: 28614300
DOI: 10.1038/nature22965
PMCID: PMC5627969

Genes

PTEN
CUL1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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