Article
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
The Journal of cell biology - 19 Jul 2004
Mitra Prasenjit, Zhang Yingjie, Rameh Lucia E, Ivshina Maria P, McCollum Dannel, Nunnari John J, Hendricks Gregory M, Kerr Monica L, Field Seth J, Cantley Lewis C, Ross Alonzo H
Abstract excerpt
The mammalian tumor suppressor, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), inhibits cell growth and survival by dephosphorylating phosphatidylinositol-(3,4,5)-trisphosphate (PI[3,4,5]P3). We have found a homologue of PTEN in the fission yeast, Schizosaccharomyces pombe (ptn1). This was an unexpected finding because yeast (S. pombe and Saccharomyces cerevisiae) lack the class I...
Topics
- Evolution, Molecular
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phosphoric Monoester Hydrolases
- Phosphotransferases (Alcohol Group Acceptor)
- Saccharomyces cerevisiae Proteins
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins