Article
Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate.
The Journal of biological chemistry - 28 Dec 2001
Gan X, Kaplan R, Menke J G, MacNaul K, Chen Y, Sparrow C P, Zhou G, Wright S D, Cai T Q
Abstract excerpt
ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor liver X receptor (LXR). In searching for potential modulators of ABCA1 expression, we have studied the effects of various...
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