Article
The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system.
The Journal of biological chemistry - 9 Jan 2004
Monaghan Alan S, Benton David C H, Bahia Parmvir K, Hosseini Ramine, Shah Yousaf A, Haylett Dennis G, Moss Guy W J
Abstract excerpt
The aim of this study was to determine whether functional heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 subunits. First, to determine whether rSK3 could co-assemble with rSK2 we created rSK3VK (an SK3 mutant insensitive to block by UCL 1848). When rSK3VK was co-expressed with rSK2 the resulting currents had an intermediate sensitivity to UCL...
Topics
- Animals
- Calcium
- Cell Line
- Dose-Response Relationship, Drug
- Electrophysiology
- Genes, Dominant
- Humans
- Immunohistochemistry
- Inhibitory Concentration 50
- Microscopy, Confocal