Article
A novel MaxiK splice variant exhibits dominant-negative properties for surface expression.
The Journal of biological chemistry - 11 May 2001
Zarei M M, Zhu N, Alioua A, Eghbali M, Stefani E, Toro L
Abstract excerpt
We identified a novel MaxiK alpha subunit splice variant (SV1) from rat myometrium that is also present in brain. SV1 has a 33-amino acid insert in the S1 transmembrane domain that does not alter S1 overall hydrophobicity, but makes the S0-S1 linker longer. SV1 was transfected in HEK293T cells and studied using immunocytochemistry and electrophysiology. In non-permeabilized cells, N-terminal c-Myc- or C-terminal...
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