A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels.

doi:10.1111/ejn.16189

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Article

A single coiled-coil domain mutation in hIKCa channel subunits disrupts preferential formation of heteromeric hSK1:hIKCa channels.

The European journal of neuroscience - 1 Jan 2024

Charlick James N, Bozadzhieva Daniella, Butler Andrew S, Wilkinson Kevin A, Marrion Neil V

Abstract excerpt

The expression of IKCa (SK4) channel subunits overlaps with that of SK channel subunits, and it has been proposed that the two related subunits prefer to co-assemble to form heteromeric hSK1:hIKCa channels. This implicates hSK1:hIKCa heteromers in physiological roles that might have been attribut...

Topics

Mutation
Neurons
Humans
Intermediate-Conductance Calcium-Activated Potassium Channels
Small-Conductance Calcium-Activated Potassium Channels

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