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Article

Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.

The Journal of physiology - 15 Nov 2002

Rajan Sindhu, Preisig-Müller Regina, Wischmeyer Erhard, Nehring Ralf, Hanley Peter J, Renigunta Vijay, Musset Boris, Schlichthörl Günter, Derst Christian, Karschin Andreas, Daut Jürgen

Abstract excerpt

The two-pore-domain potassium channels TASK-1, TASK-3 and TASK-5 possess a conserved C-terminal motif of five amino acids. Truncation of the C-terminus of TASK-1 strongly reduced the currents measured after heterologous expression in Xenopus oocytes or HEK293 cells and decreased surface membrane expression of GFP-tagged channel proteins. Two-hybrid analysis showed that the C-terminal domain of TASK-1, TASK-3 and...

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Identifiers

PMID: 12433946
DOI: 10.1113/jphysiol.2002.027052
PMCID: PMC2290646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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