Article
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway.
The Journal of biological chemistry - 26 Dec 2003
Puxeddu Efisio, Mitsutake Norisato, Knauf Jeffrey A, Moretti Sonia, Kim Hei W, Seta Karen A, Brockman Diane, Myatt Leslie, Millhorn David E, Fagin James A
Abstract excerpt
RET/PTC rearrangements are believed to be tumor-initiating events in papillary thyroid carcinomas. We identified microsomal prostaglandin E2 synthase-1 (mPGES-1) as a RET/PTC-inducible gene through subtraction hybridization cloning and expression profiling with custom microarrays. The inducible prostaglandin E2 (PGE2) biosynthetic enzymes cyclooxygenase-2 (COX-2) and mPGES-1 are up-regulated in many cancers....
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