Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.

Endocrine-related cancer - 1 Mar 2016

Romitti Mírian, Wajner Simone Magagnin, Ceolin Lucieli, Ferreira Carla Vaz, Ribeiro Rafaela Vanin Pinto, Rohenkohl Helena Cecin, Weber Shana de Souto, Lopez Patrícia Luciana da Costa, Fuziwara Cesar Seigi, Kimura Edna Teruko, Maia Ana Luiza

Abstract excerpt

Type 3 deiodinase (DIO3, D3) is reactivated in human neoplasias. Increased D3 levels in papillary thyroid carcinoma (PTC) have been associated with tumor size and metastatic disease. The objective of this study is to investigate the signaling pathways involved in DIO3 upregulation in PTC. Experiments were performed in human PTC cell lines (K1 and TPC-1 cells) or tumor samples. DIO3 mRNA and activity were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Iodide Peroxidase

Share to MAP Kinase Kinase 1

Share to p38 Mitogen-Activated Protein Kinases

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 26825960
DOI: 10.1530/ERC-15-0162

Genes

DIO3
BRAF
SHH
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.PMID 26825960Read ↗

Increased type 3 deiodinase expression in papillary thyroid carcinoma.Semantic proximity Read ↗

Type 3 deiodinase and solid tumors: an intriguing pairSemantic proximity Read ↗

The Sonic Hedgehog-Induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2 InactivationSemantic proximity Read ↗

Deiodinases and CancerSemantic proximity Read ↗

Current concepts and challenges to unravel the role of iodothyronine deiodinases in human neoplasiasSemantic proximity Read ↗

MicroRNAs in thyroid development, function and tumorigenesisSemantic proximity Read ↗

NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cells.Semantic proximity Read ↗

Pretranslational Regulation of Type 2 DeiodinaseSemantic proximity Read ↗

DLK1-DIO3 Region as a Source of Candidate Tumor Suppressor miRNAs in Papil- Lary Thyroid CarcinomaSemantic proximity Read ↗

Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells.Semantic proximity Read ↗

Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4Semantic proximity Read ↗

Thyroid Hormone Deiodinases: Dynamic Switches in Developmental TransitionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.