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Article

A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC.

Oncotarget - 13 Oct 2015

Occhi Gianluca, Barollo Susi, Regazzo Daniela, Bertazza Loris, Galuppini Francesca, Guzzardo Vincenza, Jaffrain-Rea Marie Lise, Vianello Federica, Ciato Denis, Ceccato Filippo, Watutantrige-Fernando Sara, Bisognin Andrea, Bortoluzzi Stefania, Pennelli Gianmaria, Boscaro Marco, Scaroni Carla, Mian Caterina

Abstract excerpt

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid...

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Share to Carcinoma, Papillary
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Microscopy, Fluorescence

Share to Mitogen-Activated Protein Kinases

Share to Real-Time Polymerase Chain Reaction

Share to Receptors, Aryl Hydrocarbon

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26392334
DOI: 10.18632/oncotarget.5194
PMCID: PMC4741662

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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