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Article

The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.

Endocrine-related cancer - 1 Mar 2010

Rusciano Maria Rosaria, Salzano Marcella, Monaco Sara, Sapio Maria Rosaria, Illario Maddalena, De Falco Valentina, Santoro Massimo, Campiglia Pietro, Pastore Lucio, Fenzi Gianfranco, Rossi Guido, Vitale Mario

Abstract excerpt

RET/papillary thyroid carcinoma (PTC), TRK-T, or activating mutations of Ras and BRaf are frequent genetic alterations in PTC, all leading to the activation of the extracellular-regulated kinase (Erk) cascade. The aim of this study was to investigate the role of calmodulin-dependent kinase II (Ca...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Extracellular Signal-Regulated MAP Kinases

Share to Oncogene Protein p21(ras)

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Source

Identifiers

PMID: 19903742
DOI: 10.1677/ERC-09-0214

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19903742-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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