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Article

Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma.

International journal of molecular sciences - 14 Dec 2020

Parvathareddy Sandeep Kumar, Siraj Abdul K, Annaiyappanaidu Padmanaban, Al-Sobhi Saif S, Al-Dayel Fouad, Al-Kuraya Khawla S

Abstract excerpt

The cyclooxygenase-2 (COX-2)-prostaglandin E2 (PGE2) pathway has been implicated in carcinogenesis, with BRAF mutation shown to promote PGE2 synthesis. This study was conducted to evaluate COX-2 expression in a large cohort of Middle Eastern papillary thyroid carcinoma (PTC), and further evaluate the prognostic significance of COX-2 expression in strata of BRAF mutation status. BRAF mutation analysis was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proportional Hazards Models

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

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Source

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Identifiers

PMID: 33327467
DOI: 10.3390/ijms21249498
PMCID: PMC7764962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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