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Article

Transcript Level Modulates the Inherent Oncogenicity of RET/PTC Oncoproteins

1 Jun 2009

Abstract excerpt

Mutations to the RET proto-oncogene occur in as many as one in three cases of thyroid cancer and have been detected in both the medullary (MTC) and the papillary (PTC) forms of the disease. Of the nearly 400 chromosomal rearrangements resulting in oncogenic fusion proteins that have been identified to date, the rearrangements that give rise to RET fusion oncogenes in PTC remain the paradigm for chimeric...

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PMID: 19487296
DOI: 10.1158/0008-5472.can-08-4425

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