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The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs

15 Sept 2020

Abstract excerpt

Activated B-cell (ABC)-diffuse large B-cell lymphomas (DLBCLs) are clinically aggressive and phenotypically complex malignancies, whose transformation mechanisms remain unclear. Partially differentiated antigen-secreting cells (plasmablasts) have long been regarded as cells-of-origin for these tumors, despite lack of definitive experimental evidence. Recent DLBCL reclassification based on mutational landscapes...

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PMID: 32932517
DOI: 10.1182/blood.2020005857

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