Article

Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomes

2025-08-01

Abstract excerpt

<h4>ABSTRACT</h4> Lipoprotein lipase (LPL) is critical for clearance of circulating triglycerides and for tissue fatty acid supply. LPL is primarily synthesized and secreted by adipocytes into the interstitium and must traffic from there to the abluminal/basolateral side of capillary endothelial cells. There, LPL binds glycosylphosphatidylinositol-anchored protein 1, GPIHBP1, which stabilizes the protein and faci...

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Literature Corpus work: 76857be3-9879-58f0-8f6e-5e6e88fad65e
DOI: 10.1101/2025.07.31.665751

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