Article
Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes.
The Journal of biological chemistry - 31 Oct 2003
Su Chun-Li, Sztalryd Carole, Contreras Juan Antonio, Holm Cecilia, Kimmel Alan R, Londos Constantine
Abstract excerpt
Lipolysis in adipocytes governs the release of fatty acids for the supply of energy to various tissues of the body. This reaction is mediated by hormone-sensitive lipase (HSL), a cytosolic enzyme, and perilipin, which coats the lipid droplet surface in adipocytes. Both HSL and perilipin are substrates for polyphosphorylation by protein kinase A (PKA), and phosphorylation of perilipin is required to induce HSL to...
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