Article
Somatic mitochondrial DNA mutations in adult-onset leukaemia.
Leukemia - 1 Dec 2003
He L, Luo L, Proctor S J, Middleton P G, Blakely E L, Taylor R W, Turnbull D M
Abstract excerpt
Mitochondrial genome instability has recently been demonstrated in a wide variety of human tumours and is implicated in the development of the myelodysplastic syndromes, a heterogeneous group of haematological disorders with an increased risk of malignant transformation. We therefore investigated the incidence of somatic mitochondrial DNA (mtDNA) mutations in patients with adult-onset leukaemia. We sequenced the...
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