Article
Somatic mitochondrial DNA mutations in Chinese patients with osteosarcoma.
International journal of experimental pathology - 1 Apr 2013
Yu Man, Wan Yanfang, Zou Qinghua
Abstract excerpt
Somatic mutations in mitochondrial DNA (mtDNA) have been long proposed to drive the pathogenesis and progression of human malignancies. Previous investigations have revealed a high frequency of somatic mutations in the D-loop control region of mtDNA in osteosarcoma. However, little is known with regard to whether or not somatic mutations also occur in the coding regions of mtDNA in osteosarcoma. To test this...
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