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Mitochondrial D‐loop variations in paediatric acute myeloid leukaemia: a potential prognostic marker

9 Mar 2010

Abstract excerpt

The D-Loop region of mitochondrial DNA (mtDNA) is the regulatory region for its replication and transcription. There are two hypervariable regions (HV-I, HV-II) and the rate of mutation in these regions is 100- to 200-fold that of nuclear DNA. In the current study, the entire D-loop region of mtDNA was amplified in two overlapping polymerase chain reaction fragments and variations were evaluated in 44 paediatric...

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PMID: 20230407
DOI: 10.1111/j.1365-2141.2010.08084.x

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