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Article

Novel non-neutral mitochondrial DNA mutations found in childhood acute lymphoblastic leukemia.

Clinical genetics - 1 Feb 2018

Järviaho T, Hurme-Niiranen A, Soini H K, Niinimäki R, Möttönen M, Savolainen E-R, Hinttala R, Harila-Saari A, Uusimaa J

Abstract excerpt

Mitochondria produce adenosine triphosphate (ATP) for energy requirements via the mitochondrial oxidative phosphorylation (OXPHOS) system. One of the hallmarks of cancer is the energy shift toward glycolysis. Low OXPHOS activity and increased glycolysis are associated with aggressive types of cancer. Mitochondria have their own genome (mitochondrial DNA [mtDNA]) encoding for 13 essential subunits of the OXPHOS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28708239
DOI: 10.1111/cge.13100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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