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Somatic mutations of the mitochondrial genome in Chinese patients with Ewing sarcoma.

Human pathology - 1 Jul 2013

Yu Man, Wan Yanfang, Zou Qinghua

Abstract excerpt

Somatic mutations in mitochondrial DNA (mtDNA) have been long proposed to drive initiation and progression of human malignancies. Our previous study revealed a high prevalence of somatic mutations in the D-loop region of mtDNA in Ewing sarcoma (EWS). However, it is unclear whether somatic mutations also occur in the coding regions of mtDNA in EWS. To test this possibility, in the present study, we sequenced the...

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Identifiers

PMID: 23375644
DOI: 10.1016/j.humpath.2012.11.004

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