Article
[Mutation detection of mitochondrial DNA D-loop region in bone marrow cells of acute leukemia].
Zhongguo shi yan xue ye xue za zhi - 1 Feb 2013
Han Hui, Li Da-Qi, Chen Ping, Shao Jian-Hua, Zhao Hong-Yu, Dong Xue-Bin, Gu Lin-Ping
Abstract excerpt
This study was aimed to detect the mutations and microsatellite instability (mtMSI) in mitochondrial DNA (mtDNA) D-loop region in bone marrow cells of acute leukemia (AL) patients, and to analyze their relationship with the pathogenesis of AL. 19 cases of newly diagnosed AL were enrolled in this study. Through extracting mtDNA, the D-loop region was amplified by polymerase chain reaction (PCR), the sequences of...
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