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Article

The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

Biochemistry - 28 Sept 2004

Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

P-Glycoprotein (P-gp) is an ATP-dependent drug pump that transports a broad range of compounds out of the cell. Cross-linking studies have shown that the drug-binding pocket is at the interface between the transmembrane (TM) domains and can simultaneously bind two different drug substrates. Here, we determined whether cysteine residues within the drug-binding pocket were accessible to the aqueous medium. Cysteine...

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Identifiers

PMID: 15379547
DOI: 10.1021/bi049045t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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