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Article

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.

The Biochemical journal - 15 Oct 2006

Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

P-gp (P-glycoprotein; ABCB1) protects us by transporting a broad range of structurally unrelated compounds out of the cell. Identifying the regions of P-gp that make up the drug-binding pocket is important for understanding the mechanism of transport. The common drug-binding pocket is at the interface between the transmembrane domains of the two homologous halves of P-gp. It has been shown in a previous study...

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Source

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Identifiers

PMID: 16813563
DOI: 10.1042/BJ20060715
PMCID: PMC1609921

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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