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Article

Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition.

Biochimica et biophysica acta - 1 Feb 2005

Ozvegy-Laczka Csilla, Köblös Gabriella, Sarkadi Balázs, Váradi András

Abstract excerpt

The human ABCG2 protein is an ATP binding cassette half-transporter, which protects our cells and tissues against various xenobiotics, while overexpression of ABCG2 in tumor cells confers multidrug resistance. It has been documented that single amino acid changes at position 482 resulted in altered drug resistance and transport capacity. In this study, we have generated nine Arg-482 mutants (G, I, M, S, T, D, N,...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

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Share to Benzimidazoles

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Source

Identifiers

PMID: 15670731
DOI: 10.1016/j.bbamem.2004.11.005

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition.PMID 15670731Read ↗

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