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Article

Basic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrP.

PloS one - 1 Jan 2012

Wang Wei, van Veen Hendrik W

Abstract excerpt

Secondary-active multidrug transporters can confer resistance on cells to pharmaceuticals by mediating their extrusion away from intracellular targets via substrate/H(+)(Na(+)) antiport. While the interactions of catalytic carboxylates in these transporters with coupling ions and substrates (drugs) have been studied in some detail, the functional importance of basic residues has received much less attention. The...

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Identifiers

PMID: 22761697
DOI: 10.1371/journal.pone.0038715
PMCID: PMC3380022

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