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Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein

9 Nov 2020

Abstract excerpt

P-glycoprotein (P-gp), also known as ABCB1, is a cell membrane transporter that mediates the efflux of chemically dissimilar amphipathic drugs and confers resistance to chemotherapy in most cancers. Homologous transmembrane helices (TMHs) 6 and 12 of human P-gp connect the transmembrane domains with its nucleotide-binding domains, and several residues in these TMHs contribute to the drug-binding pocket. To...

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PMID: 33168729
DOI: 10.1073/pnas.2016270117

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