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Article

Effects of antisense misexpression of CFC on downstream flectin protein expression during heart looping.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2003

Linask Kersti K, Han Ming-Da, Linask Kaari L, Schlange Thomas, Brand Thomas

Abstract excerpt

Dextral looping of the heart is regulated on multiple levels. In humans, mutations of the genes CFC and Pitx2/RIEG result in laterality-associated cardiac anomalies. In animal models, a common read-out after the misexpression of laterality genes is heart looping direction. Missing in these studies is how laterality genes impact on downstream morphogenetic processes to coordinate heart looping. Previously, we...

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PMID: 14517993
DOI: 10.1002/dvdy.10383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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