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Article

Loss of plakophilin 2 disrupts heart development in zebrafish.

The International journal of developmental biology - 1 Jan 2012

Moriarty Miriam A, Ryan Rebecca, Lalor Pierce, Dockery Peter, Byrnes Lucy, Grealy Maura

Abstract excerpt

The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. To investigate loss of function, we knocked down plakophilin 2 by morpholino microinjection in zebrafish. This resulted in decreased heart rate, cardiac oedema, blood pooling, a failure of the heart to pattern...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23124967
DOI: 10.1387/ijdb.113390mm

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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