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Article

Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2018

Hamada Shin, Shimosegawa Tooru, Taguchi Keiko, Nabeshima Tatsuhide, Yamamoto Masayuki, Masamune Atsushi

Abstract excerpt

The Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) system has a wide variety of effects in addition to the oxidative stress response, such as growth promotion and chemoresistance of cancer cells. Nrf2 is constitutively activated in most cancer cells. However, the activation of Nrf2 together with oncogenic mutations does not always result in cancer promotion. K-rasLSL-G12D/+::...

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Identifiers

PMID: 28971839
DOI: 10.1152/ajpgi.00228.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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