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Article

Regulated expression of the centrosomal protein DdCP224 affects microtubule dynamics and reveals mechanisms for the control of supernumerary centrosome number.

Molecular biology of the cell - 1 Oct 2003

Gräf Ralph, Euteneuer Ursula, Ho Thi-Hieu, Rehberg Markus

Abstract excerpt

The Dictyostelium XMAP215 family member DdCP224 is involved in centrosome duplication and cytokinesis and is concentrated at the centrosome and microtubule tips. Herein, we have created a DdCP224 promoter replacement mutant that allows both over- and underexpression. Overexpression led to supernumerary microtubule-organizing centers and, independently, an increase of the number of multinuclear cells. Electron...

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Identifiers

PMID: 14517319
DOI: 10.1091/mbc.e03-04-0242
PMCID: PMC207000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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