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Article

The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.

Molecular biology of the cell - 1 Jan 2006

Colombié Nathalie, Vérollet Christel, Sampaio Paula, Moisand André, Sunkel Claudio, Bourbon Henri-Marc, Wright Michel, Raynaud-Messina Brigitte

Abstract excerpt

Gamma-tubulin, a protein critical for microtubule assembly, functions within multiprotein complexes. However, little is known about the respective role of gamma-tubulin partners in metazoans. For the first time in a multicellular organism, we have investigated the function of Dgrip84, the Drosophila orthologue of the Saccharomyces cerevisiae gamma-tubulin-associated protein Spc97p. Mutant analysis shows that...

Topics

Animals
Cell Line
Centromere
Drosophila Proteins
Drosophila melanogaster
Male
Microscopy, Electron
Microtubule-Associated Proteins
Microtubules
Mitosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Protein Binding

Protein Subunits

RNA Interference

Spermatogenesis

Spindle Apparatus

Spodoptera

Source

Open in PubMed Open full text

Identifiers

PMID: 16236791
DOI: 10.1091/mbc.e05-08-0722
PMCID: PMC1345665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.PMID 16236791Read ↗

Drosophila melanogaster gamma-TuRC is dispensable for targeting gamma-tubulin to the centrosome and microtubule nucleation.Semantic proximity Read ↗

The gammaTuRC components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline.Semantic proximity Read ↗

The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint.Semantic proximity Read ↗

Mutation of a Drosophila gamma tubulin ring complex subunit encoded by discs degenerate-4 differentially disrupts centrosomal protein localization.Semantic proximity Read ↗

Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function.Semantic proximity Read ↗

The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis.Semantic proximity Read ↗

The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers.Semantic proximity Read ↗

Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast.Semantic proximity Read ↗

Modulation of Alp4 function in Schizosaccharomyces pombe induces novel phenotypes that imply distinct functions for nuclear and cytoplasmic gamma-tubulin complexes.Semantic proximity Read ↗

The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.Semantic proximity Read ↗

SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria.Semantic proximity Read ↗

A highly divergent gamma-tubulin gene is essential for cell growth and proper microtubule organization in Saccharomyces cerevisiae.Semantic proximity Read ↗

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