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Article

RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.

The Journal of biological chemistry - 28 May 2010

Yamada Chizu, Ozaki Toshinori, Ando Kiyohiro, Suenaga Yusuke, Inoue Ken-ichi, Ito Yoshiaki, Okoshi Rintaro, Kageyama Hajime, Kimura Hideki, Miyazaki Masaru, Nakagawara Akira

Abstract excerpt

Although it has been shown that the gastric tumor suppressor RUNX3 has a growth inhibitory activity, the precise molecular mechanisms behind RUNX3-mediated tumor suppression remained unclear. In this study, we found that RUNX3 is closely involved in DNA damage-dependent phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53. The small interference RNA-mediated knockdown of RUNX3...

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Source

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Identifiers

PMID: 20353948
DOI: 10.1074/jbc.M109.055525
PMCID: PMC2878082

Genes

RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.PMID 20353948Read ↗

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