Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation.

doi:10.1046/j.1471-4159.2003.02020.x

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Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation.

Journal of neurochemistry - 1 Oct 2003

Furukawa Katsutoshi, Wang Yue, Yao Pamela J, Fu Weiming, Mattson Mark P, Itoyama Yasuto, Onodera Hiroshi, D'Souza Ian, Poorkaj Parvone H, Bird Thomas D, Schellenberg Gerard D

Abstract excerpt

Tau, a microtubule binding protein, is not only a major component of neurofibrillary tangles in Alzheimer's disease, but also a causative gene for hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). We show here that an FTDP-17 tau mutation (V337M) in SH-SY5Y cells reduces microtubule polymerization, increases voltage-dependent calcium current (ICa) density, and decreases ICa...

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Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation.

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