Article
The tau mutation (val337met) disrupts cytoskeletal networks of microtubules.
Neuroreport - 6 Apr 1999
Arawaka S, Usami M, Sahara N, Schellenberg G D, Lee G, Mori H
Abstract excerpt
The missense point mutation found in the tau gene, which was segregated in a family with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), has proved to be the causal molecule for widely spread dementia diseases. Here we examined the effects of the tau mutation using confocal analysis. When wild-type tau cDNA was introduced into cells, extensive cell processes and well-developed thick...
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