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Article

Transthyretin oligomers induce calcium influx via voltage-gated calcium channels.

Journal of neurochemistry - 1 Jan 2007

Hou Xu, Parkington Helena C, Coleman Harold A, Mechler Adam, Martin Lisandra L, Aguilar Marie-Isabel, Small David H

Abstract excerpt

The deposition of transthyretin (TTR) amyloid in the PNS is a major pathological feature of familial amyloidotic polyneuropathy. The aim of the present study was to examine whether TTR could disrupt cytoplasmic Ca(2+) homeostasis and to determine the role of TTR aggregation in this process. The aggregation of amyloidogenic TTR was examined by solution turbidity, dynamic light scattering and atomic force...

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Source

Identifiers

PMID: 17076759
DOI: 10.1111/j.1471-4159.2006.04210.x

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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