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Article

Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism.

Neuroreport - 17 Jan 2000

Furukawa K, D'Souza I, Crudder C H, Onodera H, Itoyama Y, Poorkaj P, Bird T D, Schellenberg G D

Abstract excerpt

It was recently discovered that mutations of tau cause hereditary frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Here we report that cultured SH-SY5Y human neuroblastoma cells transfected with mutated tau genes are more vulnerable to apoptotic stimulus. Two kinds of mutations of tau causing FTDP-17 were examined in the present study: one was in exon 10 (N279K) and the other was in...

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Identifiers

PMID: 10683829
DOI: 10.1097/00001756-200001170-00011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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