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Article

The Arctic Alzheimer mutation enhances sensitivity to toxic stress in human neuroblastoma cells.

Neuroscience letters - 21 Jun 2002

Sennvik Kristina, Nilsberth Camilla, Stenh Charlotte, Lannfelt Lars, Benedikz Eirikur

Abstract excerpt

The E693G (Arctic) mutation of the amyloid precursor protein was recently found to lead to early-onset Alzheimer's disease in a Swedish family. In the present study, we report that the Arctic mutation decreases cell viability in human neuroblastoma cells. The cell viability, as measured by the MTT assay and propidium iodide staining, was further compromised following exposure to calcium ionophore A23187,...

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Identifiers

PMID: 12052536
DOI: 10.1016/s0304-3940(02)00305-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Arctic Alzheimer mutation enhances sensitivity to toxic stress in human neuroblastoma cells.PMID 12052536Read ↗

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