Article
The Arctic Alzheimer mutation enhances sensitivity to toxic stress in human neuroblastoma cells.
Neuroscience letters - 21 Jun 2002
Sennvik Kristina, Nilsberth Camilla, Stenh Charlotte, Lannfelt Lars, Benedikz Eirikur
Abstract excerpt
The E693G (Arctic) mutation of the amyloid precursor protein was recently found to lead to early-onset Alzheimer's disease in a Swedish family. In the present study, we report that the Arctic mutation decreases cell viability in human neuroblastoma cells. The cell viability, as measured by the MTT assay and propidium iodide staining, was further compromised following exposure to calcium ionophore A23187,...
Topics
- Alkaloids
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Apoptosis
- Blotting, Western
- Calcimycin
- Colchicine
- Humans
- Hydrogen Peroxide
- Ionophores
- Mutation
- Neuroblastoma
- Tumor Cells, Cultured