Gene design of signal sequence for effective secretion of protein.

doi:10.1093/nass/3.1.261

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Article

Gene design of signal sequence for effective secretion of protein.

Nucleic acids research. Supplement (2001) - 1 Jan 2003

Tsuchiya Yoshinori, Morioka Kazuki, Shirai Junsuke, Yokomizo Yuichi, Yoshida Kazuo

Abstract excerpt

To improve the secretion level of recombinant protein, the gene sequence coded the chicken lysozyme signal peptide (CLSP) connected with human lysozyme (HLY) was altered to substitute the amino acid sequence, and the effect of mutations on secretion of HLY in yeast was elucidated. The effect of mutations on secretion of recombinant HLY was elucidated in yeast. As the result of experiments, it has been shown that...

Topics

Amino Acid Sequence
Animals
Chickens
Humans
Muramidase
Mutation
Protein Sorting Signals
Recombinant Proteins

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Open in PubMed

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PMID: 14510480
DOI: 10.1093/nass/3.1.261

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