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Article

Gene design of signal sequence for the effective secretion of recombinant protein using insect cell.

Nucleic acids symposium series (2004) - 1 Jan 2005

Tsuchiya Yoshinori, Morioka Kazuki, Taneda Isao, Shirai Junsuke, Yoshida Kazuo

Abstract excerpt

In order to increase the proteinic secretion quantity of production in insect cell, the chicken lysozyme signal peptide (CLSP) was altered, and the effect of mutations on secretion of human lysozyme (HLY), the bovine interferon beta-3, and the equine interferon alpha-1 were studied. A hybrid gene composed of CLSP gene and HLY gene was used for the production of recombinant HLY in insect cell (BmN4) using vacuole...

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PMID: 17150755
DOI: 10.1093/nass/49.1.305

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