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Article

Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation.

The Journal of investigative dermatology - 1 Jan 1998

Li G, Tron V, Ho V

Abstract excerpt

Mutations of the p53 gene have been implicated as an important factor in the pathogenesis of ultraviolet light induced skin cancers. To examine the role of p53 in skin carcinogenesis, we observed the development of skin cancers in homozygous p53-deficient (-/-) mice and wild-type p53 (+/+) mice, after chronic ultraviolet B (290-320 nm) exposure. At a dose of 2 J per m2 per s of ultraviolet B for 30 min three...

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Source

Identifiers

PMID: 9424091
DOI: 10.1046/j.1523-1747.1998.00090.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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