Article
Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation.
The Journal of investigative dermatology - 1 Jan 1998
Li G, Tron V, Ho V
Abstract excerpt
Mutations of the p53 gene have been implicated as an important factor in the pathogenesis of ultraviolet light induced skin cancers. To examine the role of p53 in skin carcinogenesis, we observed the development of skin cancers in homozygous p53-deficient (-/-) mice and wild-type p53 (+/+) mice,...
Topics
- Alleles
- Animals
- Carcinoma, Squamous Cell
- Genes, p53
- Life Expectancy
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Neoplasms, Radiation-Induced
- Skin Neoplasms
- Ultraviolet Rays