Article
Radioimmunoscintigraphy of human met-expressing tumor xenografts using met3, a new monoclonal antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003
Hay Rick V, Cao Brian, Skinner R Scot, Wang Ling-Mei, Su Yanli, Resau James H, Knudsen Beatrice S, Gustafson Margaret F, Koo Han-Mo, Vande Woude George F, Gross Milton D
Abstract excerpt
PURPOSE: Inappropriate expression of the receptor tyrosine kinase Met and its ligand is associated with an aggressive phenotype and poor clinical prognosis for a wide variety of solid human tumors. We are developing imaging and therapeutic agents that target this receptor-ligand complex. In this study, we evaluated the ability of radioiodinated anti-Met monoclonal antibodies from a single hybridoma clone to image...
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