Article
Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m-labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptor.
Journal of neuro-oncology - 1 Jul 2003
Takasu Syuntaro, Takahashi Toshitada, Okamoto Sho, Oriuchi Noboru, Nakayashiki Norihisa, Okamoto Kenta, Muramatsu Hideki, Hayashi Takeshi, Nakahara Norimoto, Mizuno Masaaki, Wakabayashi Toshihiko, Higuchi Tetsuya, Endo Keigo, Kozaki Kenichi, Miyaishi Osamu, Saga Shinsuke, Ueda Ryuzo, Yoshida Jun, Yoshikawa Kazuhiro
Abstract excerpt
The type III mutant epidermal growth factor receptor (EGFR) is expressed on the cell surface of a subset of glioma, but not of normal tissues. In this study, we investigated the in vivo kinetics of 3C10 mouse monoclonal antibody (mAb), specifically recognizing the type III mutant EGFR (EGFRvIII),...
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