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Article

Four individually druggable MET hotspots mediate HGF-driven tumor progression

26 May 2014

Abstract excerpt

Activation of MET by HGF plays a key role in tumor progression. Using a recently developed llama platform that generates human-like immunoglobulins, we selected 68 different antibodies that compete with HGF for binding to MET. HGF-competing antibodies recognized 4 distinct hotspots localized in different MET domains. We identified 1 hotspot that coincides with the known HGF β chain binding site on blades 2-3 of...

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PMID: 24865428
DOI: 10.1172/jci72316

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