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Article

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.

Molecular microbiology - 1 May 2015

Sullivan James A, Tong Jie Lun, Wong Martin, Kumar Ambika, Sarkar Hajrah, Ali Sarah, Hussein Ikran, Zaman Iqra, Meredith Emma Louise, Helsby Nuala A, Hu Longqin, Wilkinson Shane R

Abstract excerpt

All living cells are subject to agents that promote DNA damage. A particularly lethal lesion are interstrand cross-links (ICL), a property exploited by several anti-cancer chemotherapies. In yeast and humans, an enzyme that plays a key role in repairing such damage are the PSO2/SNM1 nucleases. Here, we report that Trypanosoma brucei, the causative agent of African trypanosomiasis, possesses a bona fide member of...

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Identifiers

PMID: 25689597
DOI: 10.1111/mmi.12973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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