Article
Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia.
Nature genetics - 1 Mar 2003
Tanner Stephan M, Aminoff Maria, Wright Fred A, Liyanarachchi Sandya, Kuronen Mervi, Saarinen Anne, Massika Orit, Mandel Hanna, Broch Harald, de la Chapelle Albert
Abstract excerpt
The amnionless gene, Amn, on mouse chromosome 12 encodes a type I transmembrane protein that is expressed in the extraembryonic visceral layer during gastrulation. Mice homozygous with respect to the amn mutation generated by a transgene insertion have no amnion. The embryos are severely compromised, surviving to the tenth day of gestation but seem to lack the mesodermal layers that normally produce the trunk....
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