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Article

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.

Developmental biology - 15 Aug 2000

Lin X, Wei G, Shi Z, Dryer L, Esko J D, Wells D E, Matzuk M M

Abstract excerpt

Mutations in the EXT1 gene are responsible for human hereditary multiple exostosis type 1. The Drosophila EXT1 homologue, tout-velu, regulates Hedgehog diffusion and signaling, which play an important role in tissue patterning during both invertebrate and vertebrate development. The EXT1 protein is also required for the biosynthesis of heparan sulfate glycosaminoglycans that bind Hedgehog. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10926768
DOI: 10.1006/dbio.2000.9798

Genes

EXT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.PMID 10926768Read ↗

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